Date/Time
Date(s) - 20/07/2004
3:30 pm - 4:30 pm

Title: EXACT SOLUTION OF A LINEAR MOLECULAR MOTOR MODEL DRIVEN BY TWO-STEP

Speaker: Dr. Hans C. Fogedby

Institute: Institute of Physics & Astronomy
University of Aarhus, Denmark

Location: ABB 162

Description:

We investigate by analytical means the stochastic equations of motion of a linear molecular motor model based on the concept of protein friction. Solving the coupled Langevin equations originally proposed by Mogilner et al. (A. Mogilner et al., Phys. Lett. 237, 297 (1998)), and averaging over both the two-step internal conformational fluctuations and the thermal noise, we present explicit, analytical expressions for the average motion and the velocity-force relationship. Our results allow for a direct interpretation of details of this motor model which are not readily accessible from numerical solutions. In particular, we find that the model is able to predict physiologically reasonable values for the load-free motor velocity and the motor mobility.