Date(s) - 27/10/2021
3:30 pm - 4:30 pm
Dr. Anna Panchenko – Queens University
Date: October 27, 2021
Time: 3:30 PM
Title: Diving into chromatin in time and space
In eukaryotes, DNA is packaged into chromatin and is dynamically accessed during transcription and replication with high spatiotemporal precision. This seemingly contradictory task of DNA packaging and dynamic access has been a topic of our recent studies. Nucleosomes represent the basic subunits of chromatin structure and comprise a histone octamer of four types of core histones, two copies each and ~147 bp of DNA wrapped around them. Intrinsically disordered histone tails, flanking histone core domains, play critical roles in nucleosome dynamics. In addition, nucleosomes can bind linker histones to regulate the degree of chromatin compaction. To gain insights into the intrinsic dynamics of chromatin, we apply all-atom molecular dynamics simulations and develop hybrid approaches by combining experimental data with molecular modelling approaches. In my talk, I will focus on our most recent projects pertaining to the roles of histones tails, DNA methylation and linker histones in regulating the chromatin compaction and binding of partners to nucleosomes.
Host: Dr. Paul Higgs