Date/Time Date(s) - 12/11/20083:20 pm - 4:20 pm
Title: The Physics of Cell Crawling and Listeria Motility
Speaker: Dr. Andrea Liu – University of Pennsylvania
Institute: University of Pennsylvania
Location: ABB 102
Description:
When a cells crawls, its shape re-organizes via polymerization and depolymerization of a network of actin filaments. The growing ends of the filaments are localized near the outside of the cell, and their polymerization, regulated by a host of proteins, pushes the cell membrane forwards in a biological model known as the dendritic nucleation model. The same dendritic nucleation mechanism comes into play when the bacterial pathogen Listeria monocytogenes infects a cell. The bacterium hijacks the host cell’s actin machinery to create an actin network (the actin comet tail) that propels the bacterium through cells and into neighboring cells. I will discuss recent results from Brownian dynamics simulations that suggest a new picture for the physical mechanism underlying this form of motility.